The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility
Copyright policy )The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility
The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma. A total of 435 ethnically Russian subjects were recruited in this study, including 221 patients with asthma and 214 sex and age matched healthy subjects. As previously reported, the -588C/T and -23G/T polymorphisms were completely linked. The -588TT/-23TT genotype was found to be associated with decreased risk of allergic asthma after adjustment for age, gender and smoking status using multivariate logistic regression analysis (OR=0.33 95% CI 0.15-0.70, p=0.036). However, the -588CT/-23GT genotype was associated with increased risk of non-allergic asthma (OR=2.03 95% CI 1.05-3.90, p=0.06). This is a first study reporting the association between genetic variations in the glutamate cysteine ligase gene and susceptibility to bronchial asthma.
- Kursk State Medical University Russian Federation
Pulmonary and Respiratory Medicine, Adult, Male, Adolescent, Genotype, Glutamate-Cysteine Ligase, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Glutathione metabolism, Risk Factors, Glutamate cysteine ligase, Humans, Genetic Predisposition to Disease, Aged, Aged, 80 and over, Antioxidant enzyme, Middle Aged, Glutathione, Asthma, Single nucleotide polymorphism, Case–control studies, Case-Control Studies, Female
Pulmonary and Respiratory Medicine, Adult, Male, Adolescent, Genotype, Glutamate-Cysteine Ligase, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Glutathione metabolism, Risk Factors, Glutamate cysteine ligase, Humans, Genetic Predisposition to Disease, Aged, Aged, 80 and over, Antioxidant enzyme, Middle Aged, Glutathione, Asthma, Single nucleotide polymorphism, Case–control studies, Case-Control Studies, Female
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