Significance Negative-strand RNA viruses are highly pathogenic and cause many severe diseases in humans and animals. These viruses generally use existing cellular pathways to enter cells, which involves intensive interaction with the endomembrane network, offering the endocytic pathway as an attractive scheme for therapeutic intervention. Molecular mechanisms governing virus entry remain incompletely understood. We found that UV-radiation resistance-associated gene, well known for regulating autophagy and intracellular trafficking, is a critical factor for virus entry through combinatorial interactions with a tether and endosomal SNAREs. Understanding the mechanism that allows the virus to interact with late endocytic organelles could identify the specific set of proteins that have a role in virus entry, which will help us to design specific therapeutic agents against endocytic virus entries.