Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours.
Copyright policy )Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours.
This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density BDV - assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST's cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Portuguese Science and Technology Foundation: SFRH/BD/36463/2007
Portuguese Science and Technology Foundation
CNPq: 476936/2008-0
- UNIVERSIDADE DE SAO PAULO Brazil
- Molecular Oncology (United States) United States
- Universidade de São Paulo Brazil
- Federal University of Sao Paulo Brazil
- Sao Paulo State University Brazil
Male, Proto-Oncogene Proteins B-raf, Gastrointestinal Stromal Tumors, DNA Mutational Analysis, VEGF-C, Kaplan-Meier Estimate, D2-40, Antibodies, Monoclonal, Murine-Derived, Predictive Value of Tests, 616, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Lymphangiogenesis, Lymphatic Vessels, Gastrointestinal stromal tumours, KIT, Middle Aged, Prognosis, Immunohistochemistry, VEGFR-3, Platelet Endothelial Cell Adhesion Molecule-1, Mutation, Blood Vessels, Female, Brazil
Male, Proto-Oncogene Proteins B-raf, Gastrointestinal Stromal Tumors, DNA Mutational Analysis, VEGF-C, Kaplan-Meier Estimate, D2-40, Antibodies, Monoclonal, Murine-Derived, Predictive Value of Tests, 616, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Lymphangiogenesis, Lymphatic Vessels, Gastrointestinal stromal tumours, KIT, Middle Aged, Prognosis, Immunohistochemistry, VEGFR-3, Platelet Endothelial Cell Adhesion Molecule-1, Mutation, Blood Vessels, Female, Brazil
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