HLA-G, -E and -F: Allelism, function and evolution
Copyright policy )HLA-G, -E and -F: Allelism, function and evolution
The major histocompatibility complex class I genes comprise a bunch of classical genes (A, B, C), non-classical genes (E, F and G), pseudogenes and truncated genes. MHC-E, -F and -G are now considered immune "tolerization" molecules, which not only interact with NK cells but with T lymphocyte subsets and other cells and have a role in fetus acceptation. A strong positive directional selection is acting for maintaining the observed low polymorphism on E, F and G loci in human and apes. Invariance must be important for this non-classical class I proteins function.
HLA-G Antigens, Models, Molecular, Primates, Base Sequence, Histocompatibility Antigens Class I, Genetic Variation, Evolution, Molecular, Fetus, HLA Antigens, Pregnancy, Immune Tolerance, Animals, Humans, Female, HLA-E Antigens, Alleles, DNA Primers
HLA-G Antigens, Models, Molecular, Primates, Base Sequence, Histocompatibility Antigens Class I, Genetic Variation, Evolution, Molecular, Fetus, HLA Antigens, Pregnancy, Immune Tolerance, Animals, Humans, Female, HLA-E Antigens, Alleles, DNA Primers
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