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Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Dec 2015 English Publisher:Springer Science and Business Media LLCJournal:Scientific Reports, volume 5 (eissn: 2045-2322, Copyright policy )
Authors: Yanjia Chen; Hui Han; Xiaoxiang Yan; Fenghua Ding; Xiuxiu Su; Haibo Wang; Qiujing Chen; +3 Authors

doi: 10.1038/srep17632

pmid: 26621497

pmc: PMC4665081

Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease

Abstract

AbstractThis cross-sectional study tested the hypothesis that decreased serum levels of tetranectin (TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of CAD. We conducted a systematic serological and immunohistochemical (IHC) analysis to respectively compare the TN levels in serum and artery samples in CAD patients and healthy controls. Our results showed that serum levels of TN were significantly lower in patients with CAD than in healthy controls. Further analysis via trend tests revealed that serum TN levels correlated with the number of diseased arteries. Besides, the multivariate logistic regression model revealed TN as an independent factor associated with the presence of CAD. Additionally, IHC analysis showed that TN expression was significantly higher in atherosclerotic arteries as compared to healthy control tissues. In conclusion, our study suggests that increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable CAD.

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Keywords

Male, Coronary Artery Disease, Middle Aged, Coronary Vessels, Article, Cross-Sectional Studies, Gene Expression Regulation, Humans, Female, Lectins, C-Type, Biomarkers, Aged

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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Top 10%
Top 10%
Average
Green
gold
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