Morphofunctional Characteristics of Syncytiotrophoblast and Content of Heat Shock Protein 70 in It during Exacerbation of Herpesvirus Infection in Pregnant Women
Copyright policy )Morphofunctional Characteristics of Syncytiotrophoblast and Content of Heat Shock Protein 70 in It during Exacerbation of Herpesvirus Infection in Pregnant Women
Exacerbation of herpesvirus infection during pregnancy is associated with damage to syncytiotrophoblast inflicted by herpesvirus either directly or via TNF-α (due to contact of NK lymphocytes with villus surface). A sharp decrease in the content of heat shock protein with a molecular weight of 70 Da and activation of caspase-3 were noted in placenta homogenate. This leads to disturbances in syncytiotrophoblast cytosol structure and increase in the relative content of apoptotic nuclei.
Caspase 3, Pregnancy, Humans, Apoptosis, Enzyme-Linked Immunosorbent Assay, Female, HSP70 Heat-Shock Proteins, Herpesviridae Infections, Trophoblasts
Caspase 3, Pregnancy, Humans, Apoptosis, Enzyme-Linked Immunosorbent Assay, Female, HSP70 Heat-Shock Proteins, Herpesviridae Infections, Trophoblasts
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