Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases
Copyright policy )Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases
We identify the expression of PRL-3 in primary endometrioid endometrial cancer and metastases in relation to the clinicopathological characteristics.The study involved 30 patients with type I endometrial cancer. Twelve of them were diagnosed with metastases in various localization of abdomen. The PRL-3 expression was evaluated on the basis of immunohistochemistry results by the use of monoclonal antibody anti-PRL3 clone 3B6.The intensity of PRL-3 expression in correlation with tumor stage was statistically significant (p = 0.024). The strongest reaction was noted in cases classified as a 1a and 1b stage defined by FIGO. The strength of PRL-3 expression is significantly associated with the degree of histological tumor grade (p = 0.035).The strong expression of PRL-3 in the primary tumor that was significantly correlated with the grade and clinical stage suggest that PTP4A3 participates in the process of endometrial carcinogenesis.
- Medical University of Białystok Poland
- Bialystok University of Technology Poland
- Wrocław Medical University Poland
Węzły limfatyczne - patomorfologia, Adult, Białka nowotworowe - metabolizm, Lymphatic metastasis, monoclonal, Węzły limfatyczne - enzymologia, Endometrial neoplasms - enzymology, Antibodies, endometrioid - pathology, endometrioid - enzymology, Rak endometrioidalny - patomorfologia, Przerzuty do węzłów limfatycznych, Rokowanie, Stopień złośliwości nowotworu, Rak endometrioidalny - enzymologia, Humans, Przeciwciała monoklonalne, Neoplasm proteins - metabolism, Aged, Neoplasm Staging, Fosfatazy białkowo-tyrozynowe - metabolizm, Ocena stopnia zaawansowania nowotworu, Aged, 80 and over, Nowotwory błony śluzowej macicy - patomorfologia, Neoplasm grading, Carcinoma, Antibodies, Monoclonal, Lymph nodes - enzymology, Middle Aged, Prognosis, Immunohistochemistry, Immunohistochemia, Endometrial Neoplasms, Neoplasm Proteins, Protein tyrosine phosphatases - metabolism, Lymphatic Metastasis, Neoplasm staging, Female, Lymph Nodes, Nowotwory błony śluzowej macicy - enzymologia, Lymph nodes - pathology, Protein Tyrosine Phosphatases, Carcinoma, Endometrioid, Endometrial neoplasms - pathology
Węzły limfatyczne - patomorfologia, Adult, Białka nowotworowe - metabolizm, Lymphatic metastasis, monoclonal, Węzły limfatyczne - enzymologia, Endometrial neoplasms - enzymology, Antibodies, endometrioid - pathology, endometrioid - enzymology, Rak endometrioidalny - patomorfologia, Przerzuty do węzłów limfatycznych, Rokowanie, Stopień złośliwości nowotworu, Rak endometrioidalny - enzymologia, Humans, Przeciwciała monoklonalne, Neoplasm proteins - metabolism, Aged, Neoplasm Staging, Fosfatazy białkowo-tyrozynowe - metabolizm, Ocena stopnia zaawansowania nowotworu, Aged, 80 and over, Nowotwory błony śluzowej macicy - patomorfologia, Neoplasm grading, Carcinoma, Antibodies, Monoclonal, Lymph nodes - enzymology, Middle Aged, Prognosis, Immunohistochemistry, Immunohistochemia, Endometrial Neoplasms, Neoplasm Proteins, Protein tyrosine phosphatases - metabolism, Lymphatic Metastasis, Neoplasm staging, Female, Lymph Nodes, Nowotwory błony śluzowej macicy - enzymologia, Lymph nodes - pathology, Protein Tyrosine Phosphatases, Carcinoma, Endometrioid, Endometrial neoplasms - pathology
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