Genomic Organization of the Mottled Gene, the Mouse Homologue of the Human Menkes Disease Gene
Copyright policy )Genomic Organization of the Mottled Gene, the Mouse Homologue of the Human Menkes Disease Gene
The mouse homologue of the Menkes gene has been shown to span 120 kb of genomic DNA and to be similar in structure to both its human MNK homologue (ATP7A) and the Wilson disease gene (WD; ATP7B). Conservation of the majority of intron/exon boundaries among the three genes was also observed. The high overall conservation of both the Atp7a gene and the direction of transcription of the Atp7a, Pgk1, and Xnp genes between human and mouse is compatible with the evolution of an ancestral gene subject to strong evolutionary constraints lying within a locally relatively conserved region of the X chromosome.
- Institut Pasteur France
Adenosine Triphosphatases, Mice, Inbred C3H, DNA, Complementary, Polymorphism, Genetic, Base Sequence, Recombinant Fusion Proteins, Molecular Sequence Data, Chromosome Mapping, Exons, Introns, Mice, Inbred C57BL, Mice, Copper-Transporting ATPases, Dosage Compensation, Genetic, Animals, Humans, Cloning, Molecular, Carrier Proteins, Menkes Kinky Hair Syndrome, Cation Transport Proteins
Adenosine Triphosphatases, Mice, Inbred C3H, DNA, Complementary, Polymorphism, Genetic, Base Sequence, Recombinant Fusion Proteins, Molecular Sequence Data, Chromosome Mapping, Exons, Introns, Mice, Inbred C57BL, Mice, Copper-Transporting ATPases, Dosage Compensation, Genetic, Animals, Humans, Cloning, Molecular, Carrier Proteins, Menkes Kinky Hair Syndrome, Cation Transport Proteins
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