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The AXB and BXA set of recombinant inbred mouse strains

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 United States English Publisher:Springer Science and Business Media LLCJournal:Mammalian Genome, volume 3, pages 669-680 (issn: 0938-8990, eissn: 1432-1777,

Authors: Marshall, J D; Mu, J L; Cheah, Y C; Nesbitt, M N; Frankel, W N; Paigen, B;

doi: 10.1007/bf00444361

pmid: 1477475

The AXB and BXA set of recombinant inbred mouse strains

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Abstract

The recombinant inbred (RI) set of strains, AXB and BXA, derived from C57BL/6J and A/J, originally constructed and maintained at the University of California/San Diego, have been imported into The Jackson Laboratory and are now in the 29th to 59th generation of brother-sister matings. Genetic quality control testing with 45 proviral and 11 biochemical markers previously typed in this RI set indicated that five strains had been genetically contaminated sometime in the past, so these strains have been discarded. The correct and complete strain distribution patterns for 56 genetic markers are reported for the remaining RI strain set, which consists of 31 living strains and 8 extinct strains for which DNA is available. Two additional strains, AXB 12 and BXA 17, are living and may be added to the set pending further tests of genetic purity. The progenitors of this RI set differ in susceptibility to 27 infectious diseases as well as atherosclerosis, obesity, diabetes, cancer, cleft palate, and hydrocephalus. Thus, the AXB and BXA set of RI strains will be useful in the genetic analysis of several complex diseases.

Country

United States

Related Organizations

University of California, Davis
United States
University of Chicago
United States
Jackson Laboratory
United States

Keywords

Genetic Markers, Male, Species-Specificity, Databases, Factual, Genotype, Mice, Inbred A, Mice, Inbred Strains, 630, Recombination-Genetic, DNA: ge, Mice, Mice-Inbred-A: ge, Comparative-Study, Species Specificity, SUPPORT-U-S-GOVT-P-H-S, Animals, SUPPORT-NON-U-S-GOVT, Recombination, Genetic, Genetic-Markers, DNA, Mice, Inbred C57BL, Mice-Inbred-C57BL: ge, Female, Mice-Inbred-Strains: ge, Databases-Factual

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