The Human LGR7 Low‐Density Lipoprotein Class A Module Requires Calcium for Structure
Copyright policy )The Human LGR7 Low‐Density Lipoprotein Class A Module Requires Calcium for Structure
Abstract: The relaxin and INSL3 receptors, LGR7 and LGR8, are the only human G‐protein‐coupled receptors to contain a low‐density lipoprotein class‐A (LDL‐A) module. LDL‐A modules are well characterized in a variety of diverse biological functions that involve ligand binding to elicit a response. Common features of the LDL‐A modules characterized to date are the conservation of three disulfide bonds and the structural arrangement around a bound calcium ion. In this study we recombinantly produce the human LGR7 LDL‐A module for NMR studies and demonstrate that calicum is required for the module to form a stable and correctly folded structure.
- Florey Institute of Neuroscience and Mental Health Australia
- University of Melbourne Australia
Receptors, Peptide, Protein Conformation, Amino Acid Motifs, Molecular Sequence Data, Gene Expression, Membrane Proteins, Receptors, G-Protein-Coupled, Lipoproteins, LDL, Solubility, Humans, Calcium, Amino Acid Sequence, Disulfides, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Sequence Alignment
Receptors, Peptide, Protein Conformation, Amino Acid Motifs, Molecular Sequence Data, Gene Expression, Membrane Proteins, Receptors, G-Protein-Coupled, Lipoproteins, LDL, Solubility, Humans, Calcium, Amino Acid Sequence, Disulfides, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Sequence Alignment
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