Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1998 English Publisher:Elsevier BVJournal:Trends in Cell Biology, volume 8, pages 257-259 (issn: 0962-8924,

Authors: V, Lloyd; M, Ramaswami; H, Krämer;

doi: 10.1016/s0962-8924(98)01270-7

pmid: 9714595

Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery

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Abstract

Analysis of Drosophila eye-colour mutations has made seminal contributions to the fields of genetics and biochemistry. Recent findings suggest that a subset of eye-colour genes is crucial for vesicular transport of proteins to pigment granules, specialized lysosomes of eye-pigment cells. Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes.

Related Organizations

University of Arizona
United States
The University of Texas Southwestern Medical Center
United States
Mount Allison University
Canada

Keywords

Eye Color, Mutation, Animals, Drosophila, Photoreceptor Cells, Invertebrate, Lysosomes

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