I27L Polymorphism in hepatocyte nuclear factor-1α gene and type 2 diabetes mellitus: A meta-analysis of studies about orient population (Chinese and Japanese)
Copyright policy )I27L Polymorphism in hepatocyte nuclear factor-1α gene and type 2 diabetes mellitus: A meta-analysis of studies about orient population (Chinese and Japanese)
AbstractAimsThe aim of the study was to investigate the relationship between I27L variant of HNF-1α gene and type 2 diabetes mellitus (T2DM) in an/the oriental population.MethodsWe recruited 149 T2DM patients and 96 non-diabetes controls from China. The I27L polymorphism in HNF-1α gene was detected by PCR–RFLP analysis. A mete-analysis of previously published studies on I27L and T2DM of orient population and our new study was performed. Databases of MEDLINE, CBM, and the Cochrane Library (CD-ROM) were electronically searched from January 1980 to April 2008. Analysis was performed by RevMan 4.2 software which was downloaded from website of Cochrane collaboration.Results(1). The genotype distribution of I27L/exon1 polymorphism in the HNF-1α gene was in Hardy–Weinberg equilibrium (χ2=2.34, 0.05
- Sichuan University China (People's Republic of)
- West China Hospital of Sichuan University China (People's Republic of)
Meta-analysis, I27L Polymorphism, Endocrinology, Diabetes and Metabolism, Type 2 diabetes mellitus, Internal Medicine, Hepatocyte nuclear factor-1α
Meta-analysis, I27L Polymorphism, Endocrinology, Diabetes and Metabolism, Type 2 diabetes mellitus, Internal Medicine, Hepatocyte nuclear factor-1α
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