Expression of gastrin‐releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility
Copyright policy )Expression of gastrin‐releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility
Key points Increased uterine stretch appears to increase the risk of preterm labour, but the mechanism by which this might occur is unknown. Gastrin‐releasing peptide (GRP) mRNA levels are increased by stretch of myometrial explants and incubation of stretched explants in GRP antagonists can decrease their contractility. GRP may be a target for novel therapies to decrease the risk of preterm labour in women with multiple pregnancies.
- Rosie Hospital United Kingdom
- University of Cambridge United Kingdom
- Cambridge University Hospitals NHS Foundation Trust United Kingdom
Indoles, Biopsy, Gene Expression Profiling, Blotting, Western, Oxytocin, Immunohistochemistry, Mechanotransduction, Cellular, Peptide Fragments, Potassium Chloride, Receptors, Bombesin, Hormone Antagonists, Gastrin-Releasing Peptide, Pregnancy, Oxytocics, Myometrium, Humans, Premature Birth, Bombesin, Female, Oligonucleotide Array Sequence Analysis
Indoles, Biopsy, Gene Expression Profiling, Blotting, Western, Oxytocin, Immunohistochemistry, Mechanotransduction, Cellular, Peptide Fragments, Potassium Chloride, Receptors, Bombesin, Hormone Antagonists, Gastrin-Releasing Peptide, Pregnancy, Oxytocics, Myometrium, Humans, Premature Birth, Bombesin, Female, Oligonucleotide Array Sequence Analysis
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