AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
Copyright policy )AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.
Adult, Cerebral Cortex, Homeodomain Proteins, Green Fluorescent Proteins, Gene Expression Regulation, Developmental, Cell Count, Cell Differentiation, Embryo, Mammalian, Immediate-Early Proteins, Macaca fascicularis, Fetus, Ki-67 Antigen, Bromodeoxyuridine, Animals, Evoked Potentials, Visual, Humans, Adult; Animals; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Line, Transformed; Embryo, Mammalian; Embryonic Stem Cells; Evoked Potentials, Visual; Eye Proteins; Fetus; Gene Deletion; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Immediate-Early Proteins; Ki-67 Antigen; Macaca fascicularis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; PAX6 Transcription Factor; Paired Box Transcription Factors; Photic Stimulation; RNA, Messenger; Repressor Proteins; T-Box Domain Proteins; Transcription Factor AP-2; Transcription Factors; Transfection; Tumor Suppressor Proteins; Cerebral Cortex, Eye Proteins, Embryonic Stem Cells, Gene Deletion, Cell Line, Transformed
Adult, Cerebral Cortex, Homeodomain Proteins, Green Fluorescent Proteins, Gene Expression Regulation, Developmental, Cell Count, Cell Differentiation, Embryo, Mammalian, Immediate-Early Proteins, Macaca fascicularis, Fetus, Ki-67 Antigen, Bromodeoxyuridine, Animals, Evoked Potentials, Visual, Humans, Adult; Animals; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Line, Transformed; Embryo, Mammalian; Embryonic Stem Cells; Evoked Potentials, Visual; Eye Proteins; Fetus; Gene Deletion; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Immediate-Early Proteins; Ki-67 Antigen; Macaca fascicularis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; PAX6 Transcription Factor; Paired Box Transcription Factors; Photic Stimulation; RNA, Messenger; Repressor Proteins; T-Box Domain Proteins; Transcription Factor AP-2; Transcription Factors; Transfection; Tumor Suppressor Proteins; Cerebral Cortex, Eye Proteins, Embryonic Stem Cells, Gene Deletion, Cell Line, Transformed
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