Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression
Copyright policy )Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression
Key Points Hydroxyurea activates nuclear factor–κB to transcriptionally upregulate SAR1. SAR1, in turn, activates γ-globin expression through the Giα/JNK/Jun pathway.
- National Institutes of Health United States
- National Institute of Health Pakistan
Binding Sites, Proto-Oncogene Proteins c-jun, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, JNK Mitogen-Activated Protein Kinases, NF-kappa B, Gene Expression, Antineoplastic Agents, Apoptosis, Cell Cycle Checkpoints, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Hydroxyurea, RNA Interference, K562 Cells, Promoter Regions, Genetic, Cells, Cultured, Fetal Hemoglobin, Monomeric GTP-Binding Proteins, Signal Transduction
Binding Sites, Proto-Oncogene Proteins c-jun, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, JNK Mitogen-Activated Protein Kinases, NF-kappa B, Gene Expression, Antineoplastic Agents, Apoptosis, Cell Cycle Checkpoints, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Hydroxyurea, RNA Interference, K562 Cells, Promoter Regions, Genetic, Cells, Cultured, Fetal Hemoglobin, Monomeric GTP-Binding Proteins, Signal Transduction
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