The mammalian Mediator complex and its role in transcriptional regulation
Copyright policy )The mammalian Mediator complex and its role in transcriptional regulation
Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.
- University of Oklahoma Health Sciences Center United States
- University of Kansas United States
- Stowers Institute for Medical Research United States
- University of Kansas Medical Center United States
Protein Subunits, Saccharomyces cerevisiae Proteins, Gene Expression Regulation, Transcription, Genetic, Multiprotein Complexes, Animals, RNA Polymerase II, Transcription Factors
Protein Subunits, Saccharomyces cerevisiae Proteins, Gene Expression Regulation, Transcription, Genetic, Multiprotein Complexes, Animals, RNA Polymerase II, Transcription Factors
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