Anti-KIR4.1 Antibodies in Chinese Patients with Central Nervous System Inflammatory Demyelinating Disorders
Copyright policy )Anti-KIR4.1 Antibodies in Chinese Patients with Central Nervous System Inflammatory Demyelinating Disorders
<b><i>Objectives:</i></b> The aim of this study was to explore the frequency of KIR4.1 antibodies in patients with multiple sclerosis (MS) and in control groups using a cell-based assay. <b><i>Materials and Methods:</i></b> A transfected HEK-293A cell line expressing KIR4.1 was established to test for the presence of KIR4.1 antibodies in blood serum. We tested 904 subjects, including 188 patients with MS, 264 patients with neuromyelitis optica spectrum disorders (NMOSD), 209 patients with other inflammatory neurologic disease (OIND), 203 patients with other noninflammatory neurological disease (OND), and 40 healthy controls. <b><i>Results:</i></b> KIR4.1 antibodies were present in 23 of the 188 (12.2%) MS patients, 42 of the 264 (15.9%) NMOSD patients, 32 of the 209 (15.3%) OIND patients, 24 of the 203 (11.8%) OND patients, and 2 of the 40 (5%) healthy controls. There were no significant differences among the MS and control groups (<i>p</i> = 0.279). <b><i>Conclusions:</i></b> Anti-KIR4.1 antibody, as determined by a cell-based assay, is not a specific biomarker for MS.
- Second Affiliated Hospital of Guangzhou Medical University China (People's Republic of)
- Ministry of Education of the People's Republic of China China (People's Republic of)
Adult, Aged, 80 and over, Aquaporin 4, Male, Adolescent, Neuromyelitis Optica, Demyelinating Autoimmune Diseases, CNS, Middle Aged, Transfection, Young Adult, HEK293 Cells, Asian People, Kcnj10 Channel, Child, Preschool, Humans, Female, Potassium Channels, Inwardly Rectifying, Child, Aged, Autoantibodies
Adult, Aged, 80 and over, Aquaporin 4, Male, Adolescent, Neuromyelitis Optica, Demyelinating Autoimmune Diseases, CNS, Middle Aged, Transfection, Young Adult, HEK293 Cells, Asian People, Kcnj10 Channel, Child, Preschool, Humans, Female, Potassium Channels, Inwardly Rectifying, Child, Aged, Autoantibodies
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!