The Novel Sarcomeric Protein Telethonin Exhibits Developmental and Functional Regulation
Copyright policy )The Novel Sarcomeric Protein Telethonin Exhibits Developmental and Functional Regulation
We have isolated a cDNA clone from a mouse skeletal muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein. The mouse telethonin transcript is developmentally regulated in both cardiac and skeletal muscle in vivo and is down-regulated in response to denervation. In the C2C12 muscle cell-line the mouse telethonin transcript exhibited a pattern of accumulation similar to that observed for a contractile protein and suggests a role in myofibrillar assembly.
- Royal Veterinary College United Kingdom
- London North West Healthcare NHS Trust United Kingdom
- University of North London United Kingdom
Base Sequence, Myocardium, Molecular Sequence Data, Muscle Fibers, Skeletal, Down-Regulation, Gene Expression Regulation, Developmental, Muscle Proteins, Cell Line, Hindlimb, Mice, Phenotype, Organ Specificity, Animals, Humans, Connectin, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Muscle, Skeletal, Phylogeny
Base Sequence, Myocardium, Molecular Sequence Data, Muscle Fibers, Skeletal, Down-Regulation, Gene Expression Regulation, Developmental, Muscle Proteins, Cell Line, Hindlimb, Mice, Phenotype, Organ Specificity, Animals, Humans, Connectin, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Muscle, Skeletal, Phylogeny
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