gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
Copyright policy )gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
We have found that two chemokines, recombinant gro-alpha and gro-beta, specifically inhibit growth factor-stimulated proliferation of capillary endothelial cells in a dose-dependent manner, whereas gro-gamma has no inhibitory effect. In vivo, gro-beta inhibits blood vessel formation in the chicken chorioallantoic membrane assay. It is sufficiently potent to effectively suppress basic fibroblast growth factor-induced corneal neovascularization after systemic administration in mice. Further, gro-beta significantly inhibits the growth of murine Lewis lung carcinoma in syngeneic C57B16/J and immunodeficient nude mice without toxicity. In vitro, Lewis lung carcinoma cells are completely insensitive to recombinant gro-beta at high concentrations that significantly inhibit endothelial cell proliferation. This finding supports the conclusion that gro-beta inhibits Lewis lung tumor growth by suppression of tumor-induced neovascularization.
- Harvard University United States
Chemotactic Factors, Neovascularization, Pathologic, Chemokine CXCL1, Molecular Sequence Data, Mice, Nude, Chick Embryo, Growth Inhibitors, Recombinant Proteins, Mice, Inbred C57BL, Carcinoma, Lewis Lung, Mice, Consensus Sequence, Animals, Humans, Intercellular Signaling Peptides and Proteins, Amino Acid Sequence, Chemokines, Growth Substances, Chemokines, CXC, Sequence Alignment
Chemotactic Factors, Neovascularization, Pathologic, Chemokine CXCL1, Molecular Sequence Data, Mice, Nude, Chick Embryo, Growth Inhibitors, Recombinant Proteins, Mice, Inbred C57BL, Carcinoma, Lewis Lung, Mice, Consensus Sequence, Animals, Humans, Intercellular Signaling Peptides and Proteins, Amino Acid Sequence, Chemokines, Growth Substances, Chemokines, CXC, Sequence Alignment
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