SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana
Copyright policy )SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana
AbstractControl of organ size by cell proliferation and growth is a fundamental process, but the mechanisms that determine the final size of organs are largely elusive in plants. We have previously revealed that the ubiquitin receptor DA1 regulates organ size by repressing cell proliferation in Arabidopsis. Here we report that a mutant allele of STERILE APETALA (SAP) suppresses the da1-1 mutant phenotype. We show that SAP is an F-box protein that forms part of a SKP1/Cullin/F-box E3 ubiquitin ligase complex and controls organ size by promoting the proliferation of meristemoid cells. Genetic analyses suggest that SAP may act in the same pathway with PEAPOD1 and PEAPOD2, which are negative regulators of meristemoid proliferation, to control organ size, but does so independently of DA1. Further results reveal that SAP physically associates with PEAPOD1 and PEAPOD2, and targets them for degradation. These findings define a molecular mechanism by which SAP and PEAPOD control organ size.
- Chinese Academy of Sciences China (People's Republic of)
- Institute of Genetics and Developmental Biology China (People's Republic of)
- University of Chinese Academy of Sciences China (People's Republic of)
- State Key Laboratory of Plant Cell and Chromosome Engineering China (People's Republic of)
- Center for Excellence in Molecular Plant Sciences China (People's Republic of)
Proteasome Endopeptidase Complex, Saccharomyces cerevisiae Proteins, Science, Meristem, Arabidopsis, GENE FAMILY, Article, Organogenesis, Plant, Gene Expression Regulation, Plant, Plant Cells, STOMATAL DEVELOPMENT, TRANSCRIPTION FACTOR, REGULATES CELL EXPANSION, LEAF SIZE, Cell Proliferation, COMPLEX, SKP Cullin F-Box Protein Ligases, Arabidopsis Proteins, F-Box Proteins, Q, 26S PROTEASOME, PROLIFERATION, Biology and Life Sciences, Gene Expression Regulation, Developmental, Organ Size, LIM Domain Proteins, Cullin Proteins, DNA-Binding Proteins, AUXIN RECEPTOR, Phenotype, Proteolysis, GROWTH, Signal Transduction, Transcription Factors
Proteasome Endopeptidase Complex, Saccharomyces cerevisiae Proteins, Science, Meristem, Arabidopsis, GENE FAMILY, Article, Organogenesis, Plant, Gene Expression Regulation, Plant, Plant Cells, STOMATAL DEVELOPMENT, TRANSCRIPTION FACTOR, REGULATES CELL EXPANSION, LEAF SIZE, Cell Proliferation, COMPLEX, SKP Cullin F-Box Protein Ligases, Arabidopsis Proteins, F-Box Proteins, Q, 26S PROTEASOME, PROLIFERATION, Biology and Life Sciences, Gene Expression Regulation, Developmental, Organ Size, LIM Domain Proteins, Cullin Proteins, DNA-Binding Proteins, AUXIN RECEPTOR, Phenotype, Proteolysis, GROWTH, Signal Transduction, Transcription Factors
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