Induction of matrix metalloproteinase-9 in mice during Toxocara canis larvae migration
Copyright policy )Induction of matrix metalloproteinase-9 in mice during Toxocara canis larvae migration
The relationships between inflammation in organs with Toxocara canis larval migration and matrix metalloproteinase-9 (MMP-9) were investigated following the infection of mice with 1,000 infective eggs. Gelatinase activity was defined by gelatin zymography, optimum pH, inhibitor specificity and Western blot analysis. MMP-9 activity was present in the lungs, liver, muscles, and brain during T. canis larval migration. This enzyme had a molecular weight of about 94 kDa and showed maximum activity in the pH range of 6-8. The increased MMP-9 proteinases coincided with larval recovery and the degree of inflammation among the four organs. These results suggest that MMP-9 may be associated with the inflammatory reaction to larval toxocariasis during early migration, and may therefore be a useful marker during T. canis larvae migration.
Inflammation, Male, Mice, Inbred BALB C, Toxocariasis, Brain, Toxocara canis, Hydrogen-Ion Concentration, Mice, Liver, Matrix Metalloproteinase 9, Organ Specificity, Enzyme Induction, Larva, Animals, Muscle, Skeletal, Lung
Inflammation, Male, Mice, Inbred BALB C, Toxocariasis, Brain, Toxocara canis, Hydrogen-Ion Concentration, Mice, Liver, Matrix Metalloproteinase 9, Organ Specificity, Enzyme Induction, Larva, Animals, Muscle, Skeletal, Lung
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