KLF1 directly coordinates almost all aspects of terminal erythroid differentiation
Copyright policy )KLF1 directly coordinates almost all aspects of terminal erythroid differentiation
AbstractThe molecular events and transcriptional mechanisms that underlie erythropoiesis are of great interest to biologists and hematologists since disorders of erythrocytes are common and remain relatively poorly understood. Kruppel‐like factor 1 (KLF1) is a critical transcription factor for erythropoiesis in mice and man. Recently the use of chromatin immunoprecipitation (ChIP) coupled to next‐generation DNA sequencing (ChIP‐seq) has led to an updated understanding of how KLF1 functions in vivo. The full extent of KLF1 target genes have provided new insights into erythropoiesis, and have established that KLF1 controls almost all aspects of erythroid cell development and maturation. © 2010 IUBMB IUBMB Life, 62(12): 886–890
- University of Queensland Australia
- University of Queensland Australia
- Princess Alexandra Hospital Australia
- University of Queensland Australia
Chromatin Immunoprecipitation, Erythrocytes, 1303 Biochemistry, Iron, Kruppel-Like Transcription Factors, Apoptosis, 1308 Clinical Biochemistry, 1307 Cell Biology, Hemoglobins, Mice, Transcriptional regulation, 1311 Genetics, Erythroid Cells, Transcription factors, 1312 Molecular Biology, Animals, Humans, Erythropoiesis, Hemoglobin, Promoter Regions, Genetic, Mice, Knockout, Cell Cycle, Gene Expression Regulation, Developmental, Cell Differentiation, Thalassemia
Chromatin Immunoprecipitation, Erythrocytes, 1303 Biochemistry, Iron, Kruppel-Like Transcription Factors, Apoptosis, 1308 Clinical Biochemistry, 1307 Cell Biology, Hemoglobins, Mice, Transcriptional regulation, 1311 Genetics, Erythroid Cells, Transcription factors, 1312 Molecular Biology, Animals, Humans, Erythropoiesis, Hemoglobin, Promoter Regions, Genetic, Mice, Knockout, Cell Cycle, Gene Expression Regulation, Developmental, Cell Differentiation, Thalassemia
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