The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism
Copyright policy )The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism
The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration.
- Inserm France
- INSTITUT DE GENOMIQUE FONCTIONNELLE France
- French Institute of Health and Medical Research France
- University of Geneva Switzerland
- French National Centre for Scientific Research France
Cyclin-Dependent Kinase 5/metabolism, Serotonin, 616.8, Mouse, Cdk5, Neurogenesis, Down-Regulation, Cerebral Cortex/cytology/metabolism, Ligands, 5-HT6 Receptors, Substrate Specificity, Receptors, Serotonin/genetics/metabolism, Mice, Cell Movement, Animals, Humans, Migration, Research Articles, Cerebral Cortex, Neurons, Pyramidal Cells, Cyclin-Dependent Kinase 5, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, Pyramidal Cells/cytology/metabolism, HEK293 Cells, 616.89, Receptors, Serotonin, Cortex, Female, Neurons/cytology/metabolism, ddc: ddc:616.89, ddc: ddc:616.8
Cyclin-Dependent Kinase 5/metabolism, Serotonin, 616.8, Mouse, Cdk5, Neurogenesis, Down-Regulation, Cerebral Cortex/cytology/metabolism, Ligands, 5-HT6 Receptors, Substrate Specificity, Receptors, Serotonin/genetics/metabolism, Mice, Cell Movement, Animals, Humans, Migration, Research Articles, Cerebral Cortex, Neurons, Pyramidal Cells, Cyclin-Dependent Kinase 5, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, Pyramidal Cells/cytology/metabolism, HEK293 Cells, 616.89, Receptors, Serotonin, Cortex, Female, Neurons/cytology/metabolism, ddc: ddc:616.89, ddc: ddc:616.8
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).54 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!