descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 05 Jun 2018 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Signaling, volume 11 (issn: 1945-0877, eissn: 1937-9145,

Authors: Marta Portela; Liu Yang; Sayantanee Paul; Xia Li; Alexey Veraksa; Linda M. Parsons; Helena E. Richardson;

doi: 10.1126/scisignal.aar1976 , 10.26181/19306268 , 10.26181/19306268.v1 , 10.26181/19306268.v2

pmid: 29871910

pmc: PMC6437781

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

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Abstract

Lgl reduces Notch activation by cooperating with Vap33 to inhibit the vacuolar ATPase, thereby reducing endosome acidification.

Related Organizations

Spanish National Research Council
Spain
La Trobe University
Australia
Cajal Institute
Spain
University of Massachusetts Boston
United States
University of Massachusetts System
United States

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Keywords

Vacuolar Proton-Translocating ATPases, Receptors, Notch, Tumor Suppressor Proteins, Cell Polarity, Membrane Proteins, Endosomes, Eye, Epithelium, Biological sciences, Drosophila melanogaster, FOS: Biological sciences, Biochemistry and cell biology, Vacuoles, Animals, Drosophila Proteins, Female, Carrier Proteins, Acids, Signal Transduction

5 Research products, page 1 of 1

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors
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Mouse VAP33 is associated with the endoplasmic reticulum and microtubules
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Amyotrophic lateral sclerosis‐associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila
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From ER to Eph Receptors: New Roles for VAP Fragments
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Lgl protein interactome - Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex
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Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

5 Research products, page 1 of 1

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

Mouse VAP33 is associated with the endoplasmic reticulum and microtubules

Amyotrophic lateral sclerosis‐associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila

From ER to Eph Receptors: New Roles for VAP Fragments

Lgl protein interactome - Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex