The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory
Copyright policy )The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory
The active zone protein RIM1alpha is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1alpha(-/-) mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality. Our data suggest that a decrease in release probability or a loss of presynaptic LTP alone is not sufficient to cause major behavioral alterations, but the combination of presynaptic abnormalities in RIM1alpha(-/-) mice severely alters learning and memory.
- University of Strasbourg France
- Institut des Sciences Biologiques France
- The University of Texas Southwestern Medical Center United States
- Ludwig-Maximilians-Universität München Germany
- Department of Neurology Netherlands
Neuroscience(all), Blotting, Western, Conditioning, Classical, Nerve Tissue Proteins, Motor Activity, Mice, GTP-Binding Proteins, Memory, Reaction Time, Animals, Learning, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Maze Learning, In Situ Hybridization, Mice, Knockout, Membrane Glycoproteins, Behavior, Animal, Calcium-Binding Proteins, Brain, Fear, Space Perception, Psychomotor Performance
Neuroscience(all), Blotting, Western, Conditioning, Classical, Nerve Tissue Proteins, Motor Activity, Mice, GTP-Binding Proteins, Memory, Reaction Time, Animals, Learning, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Maze Learning, In Situ Hybridization, Mice, Knockout, Membrane Glycoproteins, Behavior, Animal, Calcium-Binding Proteins, Brain, Fear, Space Perception, Psychomotor Performance
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