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Seminars in Cell and Developmental Biology
Article . 2004 . Peer-reviewed
License: Elsevier TDM
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Seminars in Cell and Developmental Biology
Article . 2005
Data sources: Europe PubMed Central
Seminars in Cell and Developmental Biology
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Article . 2004
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Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2004 English Publisher:Elsevier BVJournal:Seminars in Cell & Developmental Biology, volume 15, pages 491-501 (issn: 1084-9521, Copyright policy )
Authors: Pyne, Susan; Kong, Kok-Choi; Darroch, Peter I;

doi: 10.1016/j.semcdb.2004.05.007

pmid: 15271294

Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

Abstract

The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.

Related Organizations
Keywords

570, Phosphatidate Phosphatase, 610, Membrane Proteins, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, Receptors, G-Protein-Coupled, Pharmacy and materia medica, Sphingosine, Animals, Humans, Lysophospholipids

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    		 76
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
76
Top 10%
Top 10%
Top 10%
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