Abstract:  Rheumatoid arthritis (RA) is characterized by synovial proliferation and the accumulation of inflammatory cells in the affected joints. Intercellular adhesion molecule‐1 (ICAM‐1) is readily detected in RA synovial tissues and helps recruit inflammatory cells to the joint. ICAM‐1 shows genetic polymorphisms at codons 241 (R241G) and 469 (K469E). In order to investigate the association between ICAM‐1 gene polymorphisms and RA, we genotyped ICAM‐1 R241G and ICAM‐1 K469E polymorphisms in 143 Korean patients with RA, and in 138 healthy controls, by using the polymerase chain reaction‐restriction fragment length polymorphism method. No polymorphism of R241G was found in Korean subjects. However, the frequency of the K469 allele was found to be significantly lower in RA patients than in healthy controls. Allele frequency of K469 was lower in RA patient group, compared to that in healthy controls, regardless of the shared epitope status. Distribution of K469E allele frequencies was not different whether the patient had rheumatoid factor, radiographic erosion or extra‐articular complications. In conclusion, this study shows lower frequency of the ICAM‐1 K469E allele in Korean patients with RA than that in healthy controls.