Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans
Copyright policy )Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans
DAF-2, an insulin receptor–like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.
- University of California, San Diego United States
- Scripps Research Institute United States
- University of California, San Diego United States
- Salk Institute for Biological Studies United States
Proteomics, Aging, Calcineurin, Longevity, Mass Spectrometry, Receptor, Insulin, Gene Expression Regulation, Models, Animal, Mutation, Animals, Carbohydrate Metabolism, RNA Interference, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Genes, Helminth, Signal Transduction
Proteomics, Aging, Calcineurin, Longevity, Mass Spectrometry, Receptor, Insulin, Gene Expression Regulation, Models, Animal, Mutation, Animals, Carbohydrate Metabolism, RNA Interference, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Genes, Helminth, Signal Transduction
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