Molecular analysis of HLA‐DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico
Copyright policy )Molecular analysis of HLA‐DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico
Abstract:The study of the genetics of the Major Histocompatibility Complex (MHC) in Amerindians is of great value in understanding the origins and migrations of these native groups, as well as the impact of immunogenetics on the epidemiology of diseases affecting these populations. We analyzed, using Polymerase Chain Reaction and Sequence Specific Oligonucleotide Probes (PCR‐SSOP), DRB1, DQA1, DQB1 alleles and the promoter regions of DQA1 and DQB1 genes in 31 unrelated and 24 related Seri, a Mexican Indian group, from the state of Sonora (Northwest Mexico). The class II genotypes of this population were found to be in genetic equilibrium. The allele frequency (AF) of the prevalent DRB1 alleles were DRB1*0407 (48.4%), DRB1*0802 (33.9%) and DRB1*1402 (16.1%). The most frequent DQA1 and DQB1 alleles were DQA1*03011 (AF = 50.00%), DQA1*0401 (AF = 33.87%) and DQA1*0501 (AF = 16.13%); DQB1*0302 (AF = 50.00%), DQB1*0402 (33.87%) and DQB1*0301 (16.13%); which were in combination with DRB1*0407, DRB1*0802 and DRB1*1402, respectively. Three QAP and three QBP alleles were present (QAP 3.1, 4.1, 4.2; QBP 3.1, 3.21, 4.1) associated with the typical published DQA1 and DQB1 alleles. Four class II haplotypes were present in family members: DRB1*0407‐QAP‐3.1‐DQA1*03011‐QBP‐3.21‐DQB1*0302; DRB1*0802‐QAP‐4.2‐DQA1*0401‐QBP‐4.1‐DQB1*0402; DRB1*1402‐QAP‐4.1‐DQA1*0501‐QBP‐3.1‐DQB1*0301 and DRB1*0701‐QAP‐2.1‐DQA1*0201‐QBP‐2.1‐DQB1*0201. The family data were used to confirm extended haplotypes. A total of 21 haplotypes were found when A* and B* loci were also considered. The three most frequent combinations included A*0201‐B*3501‐DRB1*0407, A*3101‐B*5101‐DRB1*0802, and A*0201‐B*40‐DRB1*1402.
Polymorphism, Genetic, HLA-DR Antigens, Emigration and Immigration, HLA-DQ alpha-Chains, Haplotypes, HLA-DQ Antigens, Indians, North American, HLA-DQ beta-Chains, Humans, Promoter Regions, Genetic, Mexico, HLA-DRB1 Chains
Polymorphism, Genetic, HLA-DR Antigens, Emigration and Immigration, HLA-DQ alpha-Chains, Haplotypes, HLA-DQ Antigens, Indians, North American, HLA-DQ beta-Chains, Humans, Promoter Regions, Genetic, Mexico, HLA-DRB1 Chains
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!