Functional conservation of hematopoietic factors in Drosophila and vertebrates
Copyright policy )Functional conservation of hematopoietic factors in Drosophila and vertebrates
The GATA, Friend of GATA, and Runt homology domain protein families function during hematopoiesis to promote progenitor cell development and regulate lineage commitment and differentiation. The hematopoietic functions of these factors have been remarkably conserved across taxonomic groups, ranging from flies to humans. Furthermore, aspects of hematopoiesis and hemocyte function appear to be conserved. Thus, comparative studies using Drosophila and vertebrate models should enhance our understanding of blood cell development.
- The University of Texas MD Anderson Cancer Center United States
Hemocytes, Nuclear Proteins, Biological Evolution, Synteny, Hematopoiesis, Neoplasm Proteins, DNA-Binding Proteins, Mice, Core Binding Factor Alpha 3 Subunit, Proto-Oncogene Proteins, Core Binding Factor Alpha 2 Subunit, Vertebrates, Animals, Drosophila, Carrier Proteins, Transcription Factors
Hemocytes, Nuclear Proteins, Biological Evolution, Synteny, Hematopoiesis, Neoplasm Proteins, DNA-Binding Proteins, Mice, Core Binding Factor Alpha 3 Subunit, Proto-Oncogene Proteins, Core Binding Factor Alpha 2 Subunit, Vertebrates, Animals, Drosophila, Carrier Proteins, Transcription Factors
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