Beginning at the end: DNA replication within the telomere
Authors: Gerbi, Susan A.;
Beginning at the end: DNA replication within the telomere
Abstract
Using single molecule analysis of replicated DNA (SMARD), Drosopoulos et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410061) report that DNA replication initiates at measurable frequency within the telomere of mouse chromosome arm 14q. They demonstrate that resolution of G4 structures on the G-rich template strand of the telomere requires some overlapping functions of BLM and WRN helicase for leading strand synthesis.
Related Organizations
- Brown University United States
Keywords
DNA Replication, RecQ Helicases, Reviews, Animals, Telomere
DNA Replication, RecQ Helicases, Reviews, Animals, Telomere
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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