Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3
Copyright policy )Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3
Immunoglobulin-like Necl-5/Tage4/poliovirus receptor (PVR)/CD155, originally identified as the PVR, has been shown to be up-regulated in cancer cells and to enhance growth factor–induced cell movement and proliferation. In addition, Necl-5 heterophilically trans-interacts with nectin-3, a cell–cell adhesion molecule known to form adherens junctions in cooperation with cadherin. We show here that Necl-5 was down-regulated from cell surface upon cell–cell contacts in NIH3T3 cells. This down-regulation of Necl-5 was initiated by its interaction with nectin-3 and was mainly mediated by clathrin-dependent endocytosis. Then, the down-regulation of Necl-5 induced in this way reduced movement and proliferation of NIH3T3 cells. These results indicate that the down-regulation of Necl-5 induced by its interaction with nectin-3 upon cell–cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation.
- Osaka University Japan
- Osaka Gakuin University Japan
Nectins, Down-Regulation, Clathrin, Endocytosis, Neoplasm Proteins, Mice, Antigens, Neoplasm, Cell Movement, Cell Adhesion, NIH 3T3 Cells, Animals, RNA, Small Interfering, Cell Adhesion Molecules, Research Articles, Cell Proliferation
Nectins, Down-Regulation, Clathrin, Endocytosis, Neoplasm Proteins, Mice, Antigens, Neoplasm, Cell Movement, Cell Adhesion, NIH 3T3 Cells, Animals, RNA, Small Interfering, Cell Adhesion Molecules, Research Articles, Cell Proliferation
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