Association between Circulating Osteocalcin and Cardiometabolic Risk Factors following a 4-Week Leafy Green Vitamin K-Rich Diet
Copyright policy )Association between Circulating Osteocalcin and Cardiometabolic Risk Factors following a 4-Week Leafy Green Vitamin K-Rich Diet
<b><i>Background:</i></b> Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. <b><i>Materials and Methods:</i></b> Men (<i>n</i> = 20) and women (<i>n</i> = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed. <b><i>Results:</i></b> Following the HK diet, ucOC and ucOC/tOC were suppressed more (<i>p</i> < 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (<i>p</i> > 0.05). <b><i>Discussion/Conclusion:</i></b> Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.
- University of Sydney
- Children's Hospital at Westmead Australia
- University of Sydney Australia
- University of Western Australia Australia
- School of Medical and Health Sciences Australia
Blood Glucose, Male, Vitamin K, Medical Sciences, Biochemical Phenomena, Carboxylated osteocalcin, Institute for Health and Sport, Osteocalcin, 610, Blood Pressure, 613, Undercarboxylated osteocalcin, Eating, Vascular Stiffness, Vegetables, Medicine and Health Sciences, Blood glucose, Humans, vitamin K1, leafy green vegetables, and Nutrition, Aged, Metabolic Syndrome, Cross-Over Studies, ucOC, Cardiometabolic Risk Factors, Vitamin K 1, Middle Aged, Arterial stiffness, Lipids, Diet, Plant Leaves, Metabolism, 1101 Medical Biochemistry and Metabolomics, Blood lipids, 1111 Nutrition and Dietetics, Female, diet
Blood Glucose, Male, Vitamin K, Medical Sciences, Biochemical Phenomena, Carboxylated osteocalcin, Institute for Health and Sport, Osteocalcin, 610, Blood Pressure, 613, Undercarboxylated osteocalcin, Eating, Vascular Stiffness, Vegetables, Medicine and Health Sciences, Blood glucose, Humans, vitamin K1, leafy green vegetables, and Nutrition, Aged, Metabolic Syndrome, Cross-Over Studies, ucOC, Cardiometabolic Risk Factors, Vitamin K 1, Middle Aged, Arterial stiffness, Lipids, Diet, Plant Leaves, Metabolism, 1101 Medical Biochemistry and Metabolomics, Blood lipids, 1111 Nutrition and Dietetics, Female, diet
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