Longitudinal MicroPET Imaging of Brain Tumor Growth with F-18-labeled RGD Peptide
Copyright policy )Longitudinal MicroPET Imaging of Brain Tumor Growth with F-18-labeled RGD Peptide
EMD 121974, a potent cyclic RGD peptide inhibitor of alphav-integrins, demonstrated effectiveness in suppressing brain tumor growth in both preclinical models and phases I/II clinical trials. The ability to non-invasively evaluate alphav-integrin expression provides a novel and unique way to better understand brain tumor angiogenesis in relationship to alphav-integrin expression, and allow for direct assessment of anti-integrin treatment efficacy.We developed a F-18-labeled RGD peptide [F-18]FB-RGD and performed serial microPET imaging scans to follow brain tumor growth and angiogenesis as a function of time in an orthotopic U87MG glioblastoma xenograft model in athymic nude mice.The tumor was barely visible on microPET at the size of
- Stanford University United States
- University of Southern California United States
- University of California System United States
- Children's Hospital of Los Angeles United States
Fluorine Radioisotopes, Brain Neoplasms, Transplantation, Heterologous, Molecular Conformation, Mice, Nude, Immunohistochemistry, Sensitivity and Specificity, Platelet Endothelial Cell Adhesion Molecule-1, Mice, Isotope Labeling, Positron-Emission Tomography, Animals, Humans, Glioblastoma, Oligopeptides, Neoplasm Transplantation
Fluorine Radioisotopes, Brain Neoplasms, Transplantation, Heterologous, Molecular Conformation, Mice, Nude, Immunohistochemistry, Sensitivity and Specificity, Platelet Endothelial Cell Adhesion Molecule-1, Mice, Isotope Labeling, Positron-Emission Tomography, Animals, Humans, Glioblastoma, Oligopeptides, Neoplasm Transplantation
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