PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1
Copyright policy )PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1
Key Points PML4 promotes erythroid differentiation in K562, primary erythroid cells, and GATA-1–rescued G1E-ER4 cells, but not in GATA-1–deficient G1E cells. PML4 interacts with GATA-1 and enhances its transcriptional activity by stimulating GATA-1/P300 cooperation and GATA-1 acetylation.
- Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
- State Key Laboratory of Medical Molecular Biology China (People's Republic of)
- Peking Union Medical College Hospital China (People's Republic of)
Transcriptional Activation, Transcription, Genetic, Tumor Suppressor Proteins, Gene Expression, Nuclear Proteins, Acetylation, Cell Differentiation, Zinc Fingers, Promyelocytic Leukemia Protein, Erythroid Cells, Trans-Activators, Humans, Protein Isoforms, GATA1 Transcription Factor, Protein Interaction Domains and Motifs, K562 Cells, E1A-Associated p300 Protein, Protein Binding, Transcription Factors
Transcriptional Activation, Transcription, Genetic, Tumor Suppressor Proteins, Gene Expression, Nuclear Proteins, Acetylation, Cell Differentiation, Zinc Fingers, Promyelocytic Leukemia Protein, Erythroid Cells, Trans-Activators, Humans, Protein Isoforms, GATA1 Transcription Factor, Protein Interaction Domains and Motifs, K562 Cells, E1A-Associated p300 Protein, Protein Binding, Transcription Factors
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