Cell-autonomous and non-cell-autonomous functions of caspase-8
Copyright policy )Cell-autonomous and non-cell-autonomous functions of caspase-8
Cells in vivo do not act in isolation. Therefore, when attempting to predict the results of pharmaceutical modulation of the function of a protein, we must also take into account the non-cell-autonomous consequences of such modulation. Studies of caspase-8 initially indicated that it serves as the proximal enzyme in cellular self-destruction dictated through the extrinsic cell-death pathway. Later studies revealed that it also participates in mechanisms affecting cell growth and survival. This essay presents a brief account of a study indicating that, apart from functional changes that are cell autonomous, tissue-specific deletion of caspase-8 in mice also has non-cell-autonomous effects with consequences that might even be the opposite of the cell-autonomous ones.
- Weizmann Institute of Science Israel
- Hebrew University of Jerusalem Israel
Caspase 8, Mice, Hepatocytes, Animals, Hepatectomy, Apoptosis, Mice, Transgenic, Enzyme Inhibitors, Gene Deletion
Caspase 8, Mice, Hepatocytes, Animals, Hepatectomy, Apoptosis, Mice, Transgenic, Enzyme Inhibitors, Gene Deletion
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