Common variants at VRK2 and TCF4 conferring risk of schizophrenia
Copyright policy )Common variants at VRK2 and TCF4 conferring risk of schizophrenia
Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10(-9)).
- Complutense University of Madrid Spain
- University of Oslo Norway
- University of Copenhagen Denmark
- Aarhus University Denmark
- KU Leuven Belgium
Risk, NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection, 572, schizophrenia; sequence variants; TCF4, Genotype, Transcription Factor, Settore MED/25 - PSICHIATRIA, 610, Protein-Serine-Threonine Kinase, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Transcription Factor 4, Humans, Genetic Predisposition to Disease, Polymorphism, Alleles, Schizophrenia; Genotype; Risk; Alleles; Polymorphism, Single Nucleotide; Transcription Factors; Humans; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Genetic Predisposition to Disease; Protein-Serine-Threonine Kinases; Genome-Wide Association Study, Allele, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Single Nucleotide, Protein-Serine-Threonine Kinases, NCEBP 1: Molecular epidemiology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factor, Schizophrenia, Human, Genome-Wide Association Study, Transcription Factors
Risk, NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection, 572, schizophrenia; sequence variants; TCF4, Genotype, Transcription Factor, Settore MED/25 - PSICHIATRIA, 610, Protein-Serine-Threonine Kinase, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Transcription Factor 4, Humans, Genetic Predisposition to Disease, Polymorphism, Alleles, Schizophrenia; Genotype; Risk; Alleles; Polymorphism, Single Nucleotide; Transcription Factors; Humans; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Genetic Predisposition to Disease; Protein-Serine-Threonine Kinases; Genome-Wide Association Study, Allele, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Single Nucleotide, Protein-Serine-Threonine Kinases, NCEBP 1: Molecular epidemiology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factor, Schizophrenia, Human, Genome-Wide Association Study, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).182 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!