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https://doi.org/10.1038/s41598...
Article . 2019 . Peer-reviewed
License: CC BY
Data sources: Crossref
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https://doi.org/10.1038/s41598...
Article
License: CC BY
Data sources: UnpayWall
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PubMed Central
Other literature type . 2019
Data sources: PubMed Central
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Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence

Authors: Beni Lestari; Ikuko Nakamae; Noriko Yoneda-Kato; Tsumoru Morimoto; Shigehiko Kanaya; Takashi Yokoyama; Masafumi Shionyu; +3 Authors

Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence

Abstract

AbstractWe previously showed that curcumin, a phytopolyphenol found in turmeric (Curcuma longa), targets a series of enzymes in the ROS metabolic pathway, induces irreversible growth arrest, and causes apoptosis. In this study, we tested Pentagamavunon-1 (PGV-1), a molecule related to curcumin, for its inhibitory activity on tumor cells in vitro and in vivo. PGV-1 exhibited 60 times lower GI50 compared to that of curcumin in K562 cells, and inhibited the proliferation of cell lines derived from leukemia, breast adenocarcinoma, cervical cancer, uterine cancer, and pancreatic cancer. The inhibition of growth by PGV-1 remained after its removal from the medium, which suggests that PGV-1 irreversibly prevents proliferation. PGV-1 specifically induced prometaphase arrest in the M phase of the cell cycle, and efficiently induced cell senescence and cell death by increasing intracellular ROS levels through inhibition of ROS-metabolic enzymes. In a xenograft mouse model, PGV-1 had marked anti-tumor activity with little side effects by oral administration, whereas curcumin rarely inhibited tumor formation by this administration. Therefore, PGV-1 is a potential therapeutic to induce tumor cell apoptosis with few side effects and low risk of relapse.

Keywords

Curcumin, Cell Death, Lactoylglutathione Lyase, Administration, Oral, Antineoplastic Agents, Phytogenic, Article, Gene Expression Regulation, Neoplastic, Alcohol Oxidoreductases, HEK293 Cells, Glutathione S-Transferase pi, Cell Movement, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, Carrier Proteins, K562 Cells, Cell Division, Cellular Senescence, Cell Proliferation, Glutathione Transferase, HeLa Cells

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
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    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
27
Top 10%
Average
Top 10%
Green
gold