M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Copyright policy )M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Significance Here, we show how, mechanistically, inflammation-recruited macrophages may stimulate beta-cell proliferation in the pancreas, and specifically identify that TGFβ1 and EGF, which are secreted by M2 macrophages, induce SMAD7 expression in beta cells. SMAD7 not only activates cell cycle activators but also induces the nuclear exclusion of cell cycle inhibitors to promote beta-cell replication. Our study thus reveals a molecular pathway to induce beta-cell proliferation through enhanced SMAD7 activity specifically in beta cells.
- University of Pittsburgh United States
- Children's Hospital of Pittsburgh United States
Cell Nucleus, Inflammation, Macrophages, Models, Biological, Smad7 Protein, Up-Regulation, ErbB Receptors, Mice, Inbred C57BL, Disease Models, Animal, Mice, Cell Movement, Transforming Growth Factor beta, Insulin-Secreting Cells, Animals, Ligation, Cyclin-Dependent Kinase Inhibitor p27, Cell Proliferation, Signal Transduction
Cell Nucleus, Inflammation, Macrophages, Models, Biological, Smad7 Protein, Up-Regulation, ErbB Receptors, Mice, Inbred C57BL, Disease Models, Animal, Mice, Cell Movement, Transforming Growth Factor beta, Insulin-Secreting Cells, Animals, Ligation, Cyclin-Dependent Kinase Inhibitor p27, Cell Proliferation, Signal Transduction
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