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Initiation of NALT Organogenesis Is Independent of the IL-7R, LTβR, and NIK Signaling Pathways but Requires the Id2 Gene and CD3−CD4+CD45+ Cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2002 English Publisher:Elsevier BVJournal:Immunity, volume 17, pages 31-40 (issn: 1074-7613,

Authors: Manabu Yanagita; Yuichi Kurono; Yoshifumi Yokota; Paul D. Rennert; Masafumi Yamamoto; Masafumi Yamamoto; Takashi Shikina; +8 Authors

doi: 10.1016/s1074-7613(02)00339-4

pmid: 12150889

Initiation of NALT Organogenesis Is Independent of the IL-7R, LTβR, and NIK Signaling Pathways but Requires the Id2 Gene and CD3−CD4+CD45+ Cells

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Abstract

Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3(-)CD4(+)CD45(+) inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.

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Keywords

CD4-Positive T-Lymphocytes, CD3 Complex, Lymphoid Tissue, Immunology, Protein Serine-Threonine Kinases, Mice, Peyer's Patches, Lymphotoxin beta Receptor, Nasopharynx, Immunology and Allergy, Animals, L-Selectin, Inhibitor of Differentiation Protein 2, Mice, Knockout, Models, Immunological, Membrane Proteins, Adoptive Transfer, DNA-Binding Proteins, Mice, Inbred C57BL, Infectious Diseases, Animals, Newborn, Antigens, Surface, Leukocyte Common Antigens

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