Development of Sensory Neurons in the Absence of NGF/TrkA Signaling In Vivo
Copyright policy )Development of Sensory Neurons in the Absence of NGF/TrkA Signaling In Vivo
The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. All dorsal root ganglion (DRG) neurons that normally die in the absence of NGF/TrkA signaling survive if BAX is also eliminated. These neurons extend axons through the dorsal roots and collateral branches into the dorsal horn. In contrast, superficial cutaneous innervation is absent. Furthermore, rescued sensory neurons fail to express biochemical markers characteristic of the nociceptive phenotype. These findings establish that NGF/TrkA signaling regulates peripheral target field innervation and is required for the full phenotypic differentiation of sensory neurons.
- Boston University United States
- University of North Carolina at Chapel Hill United States
- Albany Medical Center Hospital United States
- Center for Neurosciences United States
- University of the Sciences United States
Male, Cell Survival, Neuroscience(all), Calcitonin Gene-Related Peptide, Gene Expression Regulation, Developmental, Cell Count, Cell Differentiation, Mice, Mutant Strains, Mice, Inbred C57BL, Mice, Phenotype, Proto-Oncogene Proteins c-bcl-2, Ganglia, Spinal, Proto-Oncogene Proteins, Nerve Growth Factor, Animals, Female, Neurons, Afferent, Receptor, trkA, Cells, Cultured, Signal Transduction
Male, Cell Survival, Neuroscience(all), Calcitonin Gene-Related Peptide, Gene Expression Regulation, Developmental, Cell Count, Cell Differentiation, Mice, Mutant Strains, Mice, Inbred C57BL, Mice, Phenotype, Proto-Oncogene Proteins c-bcl-2, Ganglia, Spinal, Proto-Oncogene Proteins, Nerve Growth Factor, Animals, Female, Neurons, Afferent, Receptor, trkA, Cells, Cultured, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).334 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!