Gas access to the active site of Ni-Fe hydrogenases probed by X-ray crystallography and molecular dynamics
Copyright policy ) Y, Montet; P, Amara; A, Volbeda; X, Vernede; E C, Hatchikian; M J, Field; M, Frey; J C, Fontecilla-Camps;
Gas access to the active site of Ni-Fe hydrogenases probed by X-ray crystallography and molecular dynamics
The 2.54 A resolution structure of Ni-Fe hydrogenase has revealed the existence of hydrophobic channels connecting the molecular surface to the active site. A crystallographic analysis of xenon binding together with molecular dynamics simulations of xenon and H2 diffusion in the enzyme interior suggest that these channels serve as pathways for gas access to the active site.
Models, Molecular, Binding Sites, Xenon, Protein Conformation, Crystallography, X-Ray, Structure-Activity Relationship, Hydrogenase, Computer Simulation, Desulfovibrio, Gases, Hydrogen
Models, Molecular, Binding Sites, Xenon, Protein Conformation, Crystallography, X-Ray, Structure-Activity Relationship, Hydrogenase, Computer Simulation, Desulfovibrio, Gases, Hydrogen
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).314 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 314
Top 10%
Top 1%
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