Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch
Copyright policy )Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch
The catalytic subunit of gamma-secretase is thought to be Presenilin, which is required for both the cleavage of APP and in the processing of Notch. Presenilin is found in a multisubunit complex that also contains Nicastrin. Nicastrin has been implicated in APP processing, but its role in Notch signaling remains unclear. Here we show that Drosophila Nicastrin is required for Notch signaling, and acts specifically at the S3 cleavage step. Partially processed Notch accumulates apically in nicastrin and presenilin mutant follicle cells. nicastrin and presenilin mutations also disrupt the spectrin cytoskeleton, suggesting that the gamma-secretase complex has another function in Drosophila in addition to its role in processing Notch and APP.
- University of Cambridge United Kingdom
Membrane Glycoproteins, Receptors, Notch, Molecular Sequence Data, Membrane Proteins, Spectrin, Receptors, Cell Surface, Intracellular Membranes, Drosophila melanogaster, Bacterial Proteins, Mutation, Animals, Drosophila Proteins, Amino Acid Sequence, Amyloid Precursor Protein Secretases, Cytoskeleton, Developmental Biology, Signal Transduction
Membrane Glycoproteins, Receptors, Notch, Molecular Sequence Data, Membrane Proteins, Spectrin, Receptors, Cell Surface, Intracellular Membranes, Drosophila melanogaster, Bacterial Proteins, Mutation, Animals, Drosophila Proteins, Amino Acid Sequence, Amyloid Precursor Protein Secretases, Cytoskeleton, Developmental Biology, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).134 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!