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Advances in Enzyme Regulation
Article . 2007 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance

Authors: McCubrey J. A.; Steelman L. S.; Franklin R. A.; Abrams S. L.; Chappell W. H.; Wong E. W.; Lehmann B. D.; +6 Authors

Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance

Abstract

hematopoietic drug resistance, acute myeloid leukemia, RAF/MEK/ERK pathway, PI3K/AKT pathway, P53 pathway

Keywords

Mitogen-Activated Protein Kinase Kinases, Acute myeloid leukemia, RAF/MEK/ERK pathway, Hematopoietic drug resistance, Antineoplastic Agents, PI3K/AKT pathway, Mice, Phosphatidylinositol 3-Kinases, Drug Delivery Systems, Drug Resistance, Neoplasm, Cell Line, Tumor, Hematologic Neoplasms, Animals, raf Kinases, p53 pathway, Tumor Suppressor Protein p53, Extracellular Signal-Regulated MAP Kinases, Proto-Oncogene Proteins c-akt, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    75
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
75
Top 10%
Top 10%
Top 10%
bronze