TNF-inducible expression of lymphotoxin-β in hepatic cells: An essential role for NF-κB and Ets1 transcription factors
Copyright policy )TNF-inducible expression of lymphotoxin-β in hepatic cells: An essential role for NF-κB and Ets1 transcription factors
As TNF is one of the earliest signals that can be detected in the leukocyte-derived inflammatory cascade which drives subsequent cytokine production, we are interested in determining whether TNF is one of the initiating factors controlling liver remodeling and regeneration following chronic liver damage. One of the early responses is the expression of lymphotoxin-β by hepatic progenitor oval cells. The aim of this study was to determine whether hepatic expression of LT-β was controlled by TNF and to understand the basis of this regulation. We previously showed that LT-β expression is transcriptionally controlled via the TNF-induced, inflammatory NF-κB pathway in T lymphocytes. Here we show that TNF is able to upregulate LT-β expression in hepatic cells at the transcriptional level by the binding of NF-κB p50/p65 heterodimers and Ets1 to their respective sites in the LT-β promoter.
- University of Western Australia Australia
Lymphotoxin-beta, Transcriptional Activation, Binding Sites, Base Sequence, Sp1 Transcription Factor, Tumor Necrosis Factor-alpha, Molecular Sequence Data, NF-kappa B, Transcription Factor RelA, Hep G2 Cells, Proto-Oncogene Protein c-ets-1, Mice, Hepatocytes, Animals, Humans, Tetradecanoylphorbol Acetate, Protein Multimerization, Promoter Regions, Genetic, Early Growth Response Protein 1, Protein Binding
Lymphotoxin-beta, Transcriptional Activation, Binding Sites, Base Sequence, Sp1 Transcription Factor, Tumor Necrosis Factor-alpha, Molecular Sequence Data, NF-kappa B, Transcription Factor RelA, Hep G2 Cells, Proto-Oncogene Protein c-ets-1, Mice, Hepatocytes, Animals, Humans, Tetradecanoylphorbol Acetate, Protein Multimerization, Promoter Regions, Genetic, Early Growth Response Protein 1, Protein Binding
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