In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam
Copyright policy )In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam
Here, we report a novel narrow-spectrum β-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum β-lactamase (ESBL), by an N132D substitution, which decreased hydrolytic activities toward penicillins and cephalosporins except for mecillinam. High similarity was observed between CTX-M-215- and CTX-M-125-bearing plasmids, carried by different isolates in the same patient, indicating in vivo evolution of CTX-M-215 from CTX-M-125.
- Renji Hospital China (People's Republic of)
- Shanghai Jiao Tong University China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
- Chinese Academy of Science China (People's Republic of)
- University of Pittsburgh United States
China, Escherichia coli, Amdinocillin, Humans, Microbial Sensitivity Tests, Escherichia coli Infections, beta-Lactamases, Anti-Bacterial Agents, Plasmids
China, Escherichia coli, Amdinocillin, Humans, Microbial Sensitivity Tests, Escherichia coli Infections, beta-Lactamases, Anti-Bacterial Agents, Plasmids
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