Dorsal Pancreas Agenesis in N-Cadherin- Deficient Mice
Copyright policy )Dorsal Pancreas Agenesis in N-Cadherin- Deficient Mice
Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme.
- University of Gothenburg Sweden
- University of Pennsylvania United States
Heterozygote, Time Factors, Genotype, mesenchyme, Apoptosis, Mice, Transgenic, Mesoderm, Mice, Cell Adhesion, In Situ Nick-End Labeling, Animals, Tissue Distribution, pancreas, endoderm, Molecular Biology, Pancreas, N-cadherin, In Situ Hybridization, Endoderm, apoptosis, Cell Differentiation, Cell Biology, Cadherins, Immunohistochemistry, Microscopy, Electron, Mutation, Developmental Biology
Heterozygote, Time Factors, Genotype, mesenchyme, Apoptosis, Mice, Transgenic, Mesoderm, Mice, Cell Adhesion, In Situ Nick-End Labeling, Animals, Tissue Distribution, pancreas, endoderm, Molecular Biology, Pancreas, N-cadherin, In Situ Hybridization, Endoderm, apoptosis, Cell Differentiation, Cell Biology, Cadherins, Immunohistochemistry, Microscopy, Electron, Mutation, Developmental Biology
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