HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress
Copyright policy )HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress
Key Points Loss of the oxygen sensor PHD2 in the HSC compartment in mice results in the HIF1α-driven induction of multipotent progenitors. PHD2-deficient hematopoietic progenitors are outcompeted during severe stress while HSCs are encouraged to self-renew.
- Kings College London, University of London United Kingdom
- King's College London United Kingdom
- Max Planck Society Germany
- University of Technology Russian Federation
- University Hospital Carl Gustav Carus Germany
Mice, Knockout, Hematopoietic Stem Cells/cytology, Integrases, Multipotent Stem Cells, Cell Cycle, Procollagen-Proline Dioxygenase, 610, Procollagen-Proline Dioxygenase/physiology, Cell Differentiation, Hematopoietic Stem Cells, Hypoxia-Inducible Factor 1, alpha Subunit, Smad7 Protein/metabolism, Hypoxia-Inducible Factor-Proline Dioxygenases, Smad7 Protein, Mice, Inbred C57BL, Mice, Stress, Physiological, Animals, Multipotent Stem Cells/cytology, Hypoxia, Hypoxia/physiopathology, Integrases/metabolism, Bone Marrow Transplantation
Mice, Knockout, Hematopoietic Stem Cells/cytology, Integrases, Multipotent Stem Cells, Cell Cycle, Procollagen-Proline Dioxygenase, 610, Procollagen-Proline Dioxygenase/physiology, Cell Differentiation, Hematopoietic Stem Cells, Hypoxia-Inducible Factor 1, alpha Subunit, Smad7 Protein/metabolism, Hypoxia-Inducible Factor-Proline Dioxygenases, Smad7 Protein, Mice, Inbred C57BL, Mice, Stress, Physiological, Animals, Multipotent Stem Cells/cytology, Hypoxia, Hypoxia/physiopathology, Integrases/metabolism, Bone Marrow Transplantation
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).43 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!