Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.
Copyright policy )Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.
We have found cross-pathway regulation between purine and histidine biosynthesis in yeast. The transcription factors BAS1 and BAS2/PHO2, which are also regulators of the histidine pathway, participate in the regulation of the purine biosynthetic pathway. Analysis of four genes of the purine pathway (ADE1, ADE2, ADE5,7, and ADE8) shows that their expression is repressed by adenine. The maximal basal and induced expression of these purine genes requires the presence of both BAS1 and BAS2. The factor BAS1 has been shown to bind at a site containing the TGACTC hexanucleotide motif in the ADE2 and ADE5,7 promoters. This motif is required for both basal and induced activation of the ADE2 gene by BAS1 and BAS2.
- Massachusetts Institute of Technology United States
- Whitehead Institute for Biomedical Research United States
Homeodomain Proteins, Binding Sites, Saccharomyces cerevisiae Proteins, Base Sequence, Recombinant Fusion Proteins, Molecular Sequence Data, Restriction Mapping, Saccharomyces cerevisiae, beta-Galactosidase, Fungal Proteins, Kinetics, Oligodeoxyribonucleotides, Purines, Trans-Activators, Histidine, DNA, Fungal, Promoter Regions, Genetic, Transcription Factors
Homeodomain Proteins, Binding Sites, Saccharomyces cerevisiae Proteins, Base Sequence, Recombinant Fusion Proteins, Molecular Sequence Data, Restriction Mapping, Saccharomyces cerevisiae, beta-Galactosidase, Fungal Proteins, Kinetics, Oligodeoxyribonucleotides, Purines, Trans-Activators, Histidine, DNA, Fungal, Promoter Regions, Genetic, Transcription Factors
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