Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
Copyright policy )Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype.
- Universidade Estadual Paulista - UNESP Brazil
- Michigan State University United States
- Sao Paulo State University Brazil
- Tampere University Finland
- University of Helsinki Finland
Male, Genotype, Respiration, Cell Respiration, Gene Dosage, Supercomplexes, Cybrid, DNA, Mitochondrial, Mitochondrial DNA, Oxidative Phosphorylation, Mitochondria, Phenotype, Haplotype, Animals, Drosophila, Female
Male, Genotype, Respiration, Cell Respiration, Gene Dosage, Supercomplexes, Cybrid, DNA, Mitochondrial, Mitochondrial DNA, Oxidative Phosphorylation, Mitochondria, Phenotype, Haplotype, Animals, Drosophila, Female
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